Mention the recent confirmatory tests for CSF rhinorrhoea.

Beta 2 transferrin : sensitivity  100% , specification 95%

Beta 2 transfer is produced by neuraminidase activity within CNS. Therefore it is only present in :

  • CSF
  • Perilymph
  • Aqueous humor

This B2 transferrin is pathognomonic for CSF

  • Highly sensitive , specific and non invasive and rapid.
  • A minimum 0.5ml of fluid is necessary for electrophoresis
  • However does not provide information regarding the site or laterally of the defect .
  • Certain condition causing abnormal transferrin metabolism leading to false +ve result are inborn error of glycogen metabolism.
Tags: , , , , ,

Leave a Reply

Your email address will not be published. Required fields are marked *

error: Dr. R Content is Protected !!!
%d bloggers like this:
Skip to toolbar