- Proto-oncogenes has dominant role than tumour supressor gene in reticuloendothelial carcinoma
- Tumour supressor gene has more role in HNSCC
- E.g. PRAD1: Important oncogene in HNSCC, overexpression reduces disease free interval and overall survival after surgery
- RAS: high incidence of RAS mutation in HNSCC in india, ras mutation may be related to chewing tobacco or betel nuts.
Tags: Head and Neck Cancers