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PROTO-ONCOGENES

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  • Proto-oncogenes has dominant role than tumour supressor gene in reticuloendothelial  carcinoma
  • Tumour supressor gene has more role in HNSCC
  • E.g. PRAD1: Important oncogene in HNSCC, overexpression reduces disease free interval and overall survival after surgery
  • RAS: high incidence of RAS mutation in HNSCC in india, ras mutation may be related to chewing tobacco or betel nuts.
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