Gene therapy Virus directed enzyme prodrug therapy: induction of herpes simplex virus “thymidine kinase gene” into tumour cell leading to expression of thymidine kinase which halts DNA synthesis and decrease
Day: May 29, 2016
MOLECULAR PROGRESSION MODEL OF HNSCCMOLECULAR PROGRESSION MODEL OF HNSCC
The sequence of molecular changes in HNSCC progresses in following order : normal squamous mucosa squamous hyperplasia dysplasia carcinoma in situ invasive carcinoma metastasis
FIELD CANCERISATIONFIELD CANCERISATION
Appearance of synchronus and metachronus tumour in upper aerodigestive tract. CONCEPT: Field cancerisation could be due to mechanism underlying development of multiple primary tumour: Presence of P53 mutant and elevated