- Gene therapy
- Virus directed enzyme prodrug therapy: induction of herpes simplex virus “thymidine kinase gene” into tumour cell leading to expression of thymidine kinase which halts DNA synthesis and decrease cell growth.
- Tissue inhibitors of matrix metalloprotienase (TIMP): Tumour cell produce both metalloprotinase and their tissue inhibitor (TIMP) causing imbalance between these two leading to proteolysis and spread of the tumour.
- Antiangiogenesis agent: Angiogenesis responsible for tumour growth and invasion.
POSSIBLE FUTURE THERAPEUTIC STRATEGIES OF TREATMENT OF HNSCC
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