Proto-oncogenes has dominant role than tumour supressor gene in reticuloendothelial carcinoma Tumour supressor gene has more role in HNSCC E.g. PRAD1: Important oncogene in HNSCC, overexpression reduces disease free interval
Day: May 19, 2016
TUMOUR SUPRESSION GENETUMOUR SUPRESSION GENE
Most common target for genetic alteration Homologous loss of P53 found in every type of Ca. P53 is the most extensively studied of known tumour supressor gene FUNCTION: Induces G1
IMMUNOTHERAPY IN TREATMENT OF HNSCCIMMUNOTHERAPY IN TREATMENT OF HNSCC
HNSCC cell secrete immunoregulatory cytokines IL-2, IL-4, IL-6 These IL effect growth inhibition directly or indirectly E.g. Local treatment with IL-2 given transmural injection in recurrent HNSCC: positive response IL-2