TUMOUR SUPRESSION GENE
- Most common target for genetic alteration
- Homologous loss of P53 found in every type of Ca.
- P53 is the most extensively studied of known tumour supressor gene
- Induces G1 arrest until repair is complete
- If above is not possible- direct cell to apoptotic pathway
If P53 gene supressed (mutated), they are unable to perform above function causing outgrowth of cell I.E. Malignant clones.