TUMOUR SUPRESSION GENE

• Most common target for genetic alteration
• Homologous loss of P53 found in every type of Ca.
• P53 is the most extensively studied of known tumour supressor gene

FUNCTION:

1. Induces G1 arrest until repair is complete
2. If above is not possible- direct cell to apoptotic pathway

If P53 gene supressed (mutated), they are unable to perform above function causing outgrowth of cell I.E. Malignant clones.